The Big C

Cathy meets someone new to feel sexy again. Meanwhile, Cathy's eccentric brother Sean tries to keep his building and Adam is caught while watching pornography.

Cathy needs a lump on her butt removed and someone to pick her up after surgery. She asks Marlene, who becomes disoriented - so Lenny picks up Cathy instead. Sean moves into Cathy's backyard because he got beat up on the streets. Paul and Adam win the local bathtub races. The event brings Cathy and Paul back together, but at the point of reconciliation, Paul confesses to an indiscretion with Tina and Cathy rejects the reunion. Meanwhile, Andrea breaks into the school and destroys the mural Lenny painted.

Cathy and Sean hit the open road to visit their dad. During the trip, Cathy tells Sean she has cancer. Sean falls apart at the news, so Cathy pretends it was a big joke. Adam gets drunk while under the supervision of Paul. Marlene finds Adam on the front lawn puking. Marlene will keep it a secret, but Adam is in further servitude to her.

For her birthday, Paul surprises Cathy with a party just when Lenny has invited her to an art opening on the Bahamas. At the party, Cathy's brother begins a fling with Cathy's eccentric college friend Rebecca. Meanwhile, picks up Marlene who is wandering around in the backyard.

Dr. Todd tells Cathy that she's been rejected from the clinical trial. Sean sets up Marlene on a date. At a party, Adam gets into a fight with Andrea. Cathy and Lenny take ecstasy together. Paul catches Cathy and Lenny having sex. Paul gets too drunk at the dinner to celebrate his promotion, forcing Adam to drive home. Paul tells Cathy he wants a divorce.

Cathy's unexpected visit to Andrea's home yields many surprises. Later, Cathy seeks spiritual advice at church and while helping around the house. Rebecca calls it quits with Sean in order to reconcile her friendship with Cathy. Adam apologizes to Andrea. Paul sleeps with Tina. Cathy reveals to Paul she has cancer.

Paul seeks support from people at his work place, but gets more than he bargained for. Sean pulls away from Rebecca when it appears she's getting too serious. Cathy, Marlene and Rebecca have a girl's lunch at a strip joint -- which unexpectedly influences Cathy's thoughts about her cancer. Adam meets a girl, Mia, at the bus stop.

Dr. Todd and Cathy go to see the Bee Man to seek non-traditional treatment for her cancer. Paul is overly supportive of Cathy around the house. Sean gives Adam relationship advice about Mia.

Rebecca reveals a secret to Sean that reconnects them. Dr. Todd tells Paul and Cathy that the bee therapy did not work. Cathy reconsiders her options. Adam finally shows his softer side in an unexpected way.